Clinical Studies

Huperzine A

Research continues to suggest that Huperzine A safely enhances memory and learning in human participants, such as the adolescent Chinese students whose learning performance was improved through Huperzine A supplementation.

McDougall, G. J., Austin-Wells, V., & Zimmerman, T. (2005). Utility Of Nutraceutical Products Marketed For Cognitive And Memory Enhancement.Journal of Holistic Nursing, 23(4), 415-433.

Huperzine A is also a safe and effective remedy for Alzheimer’s disease.

Mazurek, A. (1999). An open label trial of Huperzine A in the treatment of Alzheimer’s disease. Alternative Therapies, 5(2:97), 97-98.

Huperzine A enhances focus, retention and muscular control by increasing the supply of acetylcholine in the brain.

Raves, M., Harel, M., Pang, Y., Silman, I., Kozikowski, A., & Sussman, J. (1997). Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.. Nature Structural Biology,4, 57 – 63.

Acetyl-L-Carnitine

Fights age-related decline in mental function.  

Ramacci, M., Cairns, M., Wilton-Cox, H., & Dowson, J. (1992). The morphology of lipopigment in rat Purkinje neurons after chronic acetyl-L-carnitine administration: a reduction in aging-related changes..Biological Psychiatry, 32(2), 179-87.

Increases performance on all metrics of cognitive functioning, including memory performance and constructional thinking.

Chiari, G., & Cipolli, C. (1990). Effects of L-acetylcarnitine on mental deterioration in the aged: initial results. Clinical Therapeutics, 6, 132: 479-510.

Promotes happiness.

Ancona, L., Calvani, M., Janiri, L., Pirrongelli, C., Casella, L., & Tempesta, E. (1987). L-acetylcarnitine in depressed elderly subjects. A cross-over study vs placebo.. Drugs Under Experimental and Clinical Research, 13(7), 417-23.

Zotti, C., Petrelli, G., Lecciso, G., Fiore, A., Corallo, D., & Garzya, G. (1990). Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression.. Drugs Under Experimental and Clinical Research,16(2), 101-6.

Boosts mental energy and focus.  

Pistarini, C., Fugazza, G., & Guarnaschelli, C. (1988). Pathological brain ageing: evaluation of the efficacy of a pharmacological aid.. Drugs Under Experimental and Clinical Research,14(11), 715-8.

Alpha GPC

Catalyzes the production of acetylcholine, a neurotransmitter that supports memory, cognition and neuromuscular control.

Blusztajn, J. (1998). Choline, a Vital Amine. Developmental Neuroscience,281(5378), 794-795.

Zeisel, S. (2000). Choline: an essential nutrient for humans.. Nutrition, 16, 669-71.

When combined with several of the ingredients in Mental Mojo, Alpha GPC improves cognitive function while reducing oxidative stress on the brain.

Shea, T., Suchy, J., & Chan, A. (2009). Dietary supplementation with a combination of α-lipoic acid, acetyl-l-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance. Nutrition Research, 29(1), 70 – 74.

Delays age-related cognitive and memory decline.

Blusztajn, J. (1998). Choline, a Vital Amine. Developmental Neuroscience,281(5378), 794-795; Zeisel, S. (2000), Choline: an essential nutrient for humans,  Nutrition, 16, 669-71.

Vinpocetine

“Vinpocetine is one of the few substances studied which can offer multiple cognitive benefits as well as a remarkable number of benefits for the body. It turns up our mind and keeps our lights bright at the same time in that it helps our cardiovascular and GI systems, along with muscles, joints, and sensory organs to function better.”

Jha, M., Rahman, M., & Sheikh, H. (2011). VINPOCETINE: A SMART DRUG AND A SMART NUTRIENT: A REVIEW. The International Journal of Pharmaceutical Sciences and Research, 3(2), 346-352.

Improves long and short term memory, enhances alertness, and delays age-related cognitive decline.

Jha, M., Rahman, M., & Sheikh, H. (2011). VINPOCETINE: A SMART DRUG AND A SMART NUTRIENT: A REVIEW. The International Journal of Pharmaceutical Sciences and Research, 3(2), 346-352.

Enhances oxygen and nutrient delivery to brain cells while protecting them from oxidative stress.

Jha, M., Rahman, M., & Sheikh, H. (2011). VINPOCETINE: A SMART DRUG AND A SMART NUTRIENT: A REVIEW. The International Journal of Pharmaceutical Sciences and Research, 3(2), 346-352.

Increases blood flow and metabolism within the brain.  

Szapáry, L., Fehér, G., & Bagoly, E. (2007). The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies. Hungarian Medical Journal, 148(29), 1353-8.

L-Tyrosine

Promotes longer-lasting focus by improving mental endurance.

Jäger, R., Purpura, M., Olson, M., Hoffman, M., Beller, N., Gonzalez, A., et al. (2010). The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students.. Journal of International Society of Sports Nutrition, 7, 39.

Increases motivation by catalyzing dopamine turnover.

Growdon, J. H., Melamed, E., Logue, M., Hefti, F., & Wurtman, R. J. (1982). Effects Of Oral L-tyrosine Administration Of CSF Tyrosine And Homovanillic Acid Levels In Patients With Parkinson’s Disease. Life Sciences, 30(10), 827-832.

Supports fat loss.

Meijssen, S., Erkelens, D., Bilecen, S., Derksen, R., Ballieux, C., & Cabezas, M. (2001). Insulin Mediated Inhibition Of Hormone Sensitive Lipase Activity In Vivo In Relation To Endogenous Catecholamines In Healthy Subjects. Journal of Clinical Endocrinology & metabolism , 86(9), 4193-4197.

Elevates mood while supporting memory and learning.

Deijen, J., & Orlebeke, J. (1994). Effect Of Tyrosine On Cognitive Function And Blood Pressure Under Stress. Brain Research Bulletin, 33(3), 319-323; Grevet, E. H., Tietzmann, M. R., Shansis, F. M., Hastenpflug, C., Santana, L. C., Forster, L., et al. (2002). Behavioural Effects Of Acute Phenylalanine And Tyrosine Depletion In Healthy Male Volunteers. Journal of Psychopharmacology, 16(1), 51-55.

Phosphatidylserine

Promotes memory formation and improves recall.

Einstein, G., Maier, S., & McDaniel, M. (2003). “Brain-specific” nutrients: a memory cure?. Nutrition, 19, 957-75; Massari, D., Nunzi, M., Petrie, W., Yesavage, J., Tinklenberg, J., & Crook, T. (1991). Effects of phosphatidylserine in age-associated memory impairment..Neurology, 41, 644-9.

Alleviates stress and anxiety.  

Baumeister, J., Barthel, T., Geiss, K., & Weiss, M. (2008). Influence Of Phosphatidylserine On Cognitive Performance And Cortical Activity After Induced Stress. Nutritional Neuroscience,11(3), 103-110; Hellhammer, J., Fries, E., Buss, C., Engert, V., Tuch, A., Rutenberg, D., et al. (2004). Effects Of Soy Lecithin Phosphatidic Acid And Phosphatidylserine Complex (PAS) On The Endocrine And Psychological Responses To Mental Stress. Stress: The International Journal on the Biology of Stress, 7(2), 119-126.

Increases supply of acetylcholine in the brain, which–in addition to enhancing focus, memory and neuromuscular control–combats age-related cognitive decline.

Lerer, B., Oppenheim, Y., Kelly, D., Gorfine, M., Kampf-Sherf, O., & Schreiber, S. (2000). An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline.. The Israel Journal of Psychiatry and Related Sciences, 37(4), 302-7; Kidd, P. (2005). Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and prospects for brain rebuilding using integrative management.. Alternative Medicine Review: A Journal Of Clinical Therapeutic, 10(4), 268-93.